actinomycin VI
- Norine ID: NOR00233
- DOI: 10.26097/nor00233
- Family: actinomycin
- Synonym(s): actinomycin VI;
- Activity: antimicrobial, antitumor
- Category: chromopeptide
- Formula: C63H88N12O16
- Monoisotopic mass: 1268.6441248279998 g/mol
- Comment: The principal effect of D-alloisoleucine and, especially, D-isoleucine, is to bring about synthesis of two new actinomycins which contain N-methylisoleucine.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: double cyclic
- Number of monomers: 11
- Smiles: CCC(C)C6NC(=O)C(NC(=O)C4=C(N)C(=O)C(C)=C3Oc5c(C)ccc(C(=O)NC1C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2(C(=O)C(NC1(=O))C(C)C))c5(N=C34))C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C7CCCN7(C6(=O))
- Graph inference:
- Monomeric composition :
1 D-aIle 2 Pro 3 NMe-Gly 4 NMe-Val 5 Thr 6 ChrAct 7 Thr 8 D-Val 9 Pro 10 NMe-Gly 11 NMe-Val - Graph representation: D-aIle,Pro,NMe-Gly,NMe-Val,Thr,ChrAct,Thr,D-Val,Pro,NMe-Gly,NMe-Val @1,4 @0,2 @1,3 @2,4 @0,3,5 @4,6 @5,7,10 @6,8 @7,9 @8,10 @6,9
- Atomic structure:
- Streptomyces chrysomallus
- gram: positive
- synonyms: Streptomyces anulatus,Streptomyces fluorescens,Streptomyces citreofluorescens,Actinomyces fluorescens,Actinomyces citreofluorescens,Actinomyces annulatus,Actinomyces Streptothrix annulatus
- taxid: 1892 (view NCBI taxonomy browser)
- Streptomyces sp.
- gram: positive
- synonyms:
- taxid: 1931 (view NCBI taxonomy browser)
- Links between organisms producing the actinomycin VI: Streptomyces chrysomallus, Streptomyces sp.
- Role of valine and isoleucine as regulators of actinomycin peptide formation by Streptomyces chrysomallus
Katz E, WALDRON CR, MELONI ML, Journal of bacteriology , 1961, Oct,82:600-8.
pubMed: 14454374
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