Norine

• Norine ID: NOR00235
• DOI: 10.26097/nor00235
• Family: actinomycin
• Synonym(s): actinomycin Z1;
• Activity: antimicrobial
• Category: chromopeptide
• Formula: C62H84N12O19
• Monoisotopic mass: 1300.597568566 g/mol
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: double cyclic
• Number of monomers: 11
• Smiles: CC(C)C6NC(=O)C(NC(=O)c3ccc(C)c4OC5=C(C)C(=O)C(N)=C(C(=O)NC1C(=O)NC(C(C)C)C(=O)N2C(C)C(=O)CC2(C(=O)N(C)CC(=O)N(C)C(C)C(=O)OC1(CO)))C5(=Nc34))C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C7C(O)CC(C)N7(C6(=O))
  
  
• Graph inference:


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• Monomeric composition :

  1 D-Val

  2 3OH-5Me-Pro

  3 NMe-Gly

  4 NMe-Val

  5 Thr

  6 ChrAct

  7 4OH-Thr

  8 D-Val

  9 4oxo-5Me-Pro

  10 NMe-Gly

  11 NMe-Ala

• Graph representation: D-Val,3OH-5Me-Pro,NMe-Gly,NMe-Val,Thr,ChrAct,4OH-Thr,D-Val,4oxo-5Me-Pro,NMe-Gly,NMe-Ala @1,4 @0,2 @1,3 @2,4 @0,3,5 @4,6 @5,7,10 @6,8 @7,9 @8,10 @6,9
  
  
• Atomic structure:

vizualisation:

• Streptomyces fradiae
• gram: positive
• synonyms: Streptomyces roseoflavus,Streptomyces fradii,Actinomyces fradii,Streptomyces roseiflavus
• taxid: 1906 (view NCBI taxonomy browser)

• Streptomyces sp.
• gram: positive
• synonyms:
• taxid: 1931 (view NCBI taxonomy browser)

• Links between organisms producing the actinomycin Z1: Streptomyces fradiae, Streptomyces sp.

• Structures of five components of the actinomycin Z complex from Streptomyces fradiae, two of which contain 4-chlorothreonine
  MAUGER AB, Lackner H, Bahner I, Shigematsu N, Pannell LK, Journal of natural products , 2000, Mar,63(3):352-6.
  DOI: 10.1021/np990416u
  pubMed: 10757717