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actinomycin Z5


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  • Norine ID: NOR00239
  • DOI: 10.26097/nor00239
  • Family: actinomycin
  • Synonym(s): actinomycin Z5;
  • Activity: antimicrobial
  • Category: chromopeptide
  • Formula: C62H83ClN12O17
  • Monoisotopic mass: 1302.568767 g/mol
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
  • Type: double cyclic
  • Number of monomers: 11
  • Smiles: CC(C)C6NC(=O)C(NC(=O)c3ccc(C)c4OC5=C(C)C(=O)C(N)=C(C(=O)NC1C(=O)NC(C(C)C)C(=O)N2C(C)C(=O)CC2(C(=O)N(C)CC(=O)N(C)C(C)C(=O)OC1(CCl)))C5(=Nc34))C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C7CCC(C)N7(C6(=O))

  • Graph inference:



  • Monomeric composition :
    1
    D-Val
    2
    5Me-Pro
    3
    NMe-Gly
    4
    NMe-Val
    5
    Thr
    6
    ChrAct
    7
    4Cl-Thr
    8
    D-Val
    9
    4oxo-5Me-Pro
    10
    NMe-Gly
    11
    NMe-Ala
  • Graph representation: D-Val,5Me-Pro,NMe-Gly,NMe-Val,Thr,ChrAct,4Cl-Thr,D-Val,4oxo-5Me-Pro,NMe-Gly,NMe-Ala @1,4 @0,2 @1,3 @2,4 @0,3,5 @4,6 @5,7,10 @6,8 @7,9 @8,10 @6,9

  • Atomic structure:
    • Chemical structure
    rBAN vizualisation:
  • Streptomyces sp.
  • gram: positive
  • synonyms:
  • taxid: 1931 (view NCBI taxonomy browser)

  • Links between organisms producing the actinomycin Z5: Streptomyces sp.
  • Structures of five components of the actinomycin Z complex from Streptomyces fradiae, two of which contain 4-chlorothreonine
    MAUGER AB, Lackner H, Bahner I, Shigematsu N, Pannell LK, Journal of natural products , 2000, Mar,63(3):352-6.
    DOI: 10.1021/np990416u
    pubMed: 10757717


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