Norine

• Type: partial cyclic
• Number of monomers: 11
• Smiles: COC(c1ccc(O)cc1)C2NC(=O)C(CCC(N)=O)N(C)C(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(O)C(O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(C)C(O)C(C)CC(C)C)C(C)C(C)C(N)=O)C(C)OC(=O)C(C)N(C)C2(=O))C(C)O
  
  
• Graph inference:


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• Monomeric composition :

  1 iC8:0-Me(2.4)-OH(3)

  2 D-Ala

  3 Agdha

  4 3Me-4Me-Gln

  5 D-aThr

  6 D-aThr

  7 D-Arg

  8 Leu

  9 NMe-Gln

  10 bOMe-Tyr

  11 NMe-Ala

• Graph representation: iC8:0-Me(2.4)-OH(3),D-Ala,Agdha,3Me-4Me-Gln,D-aThr,D-aThr,D-Arg,Leu,NMe-Gln,bOMe-Tyr,NMe-Ala @1 @0,2 @1,3 @2,4 @3,5,10 @4,6 @5,7 @6,8 @7,9 @8,10 @4,9
  
  
• Atomic structure:

vizualisation:

• Callipelta sp.

• Latrunculia sp.

• Links between organisms producing the callipeltin A: Callipelta sp., Latrunculia sp.

• Callipeltin A, a cyclic depsipeptide inhibitor of the cardiac sodium-calcium exchanger and positive inotropic agent
  Trevisi L, Bova S, Cargnelli G, Danieli-Betto D, Floreani M, Germinario E, D Auria MV, Luciani S, Biochemical and biophysical research communications , 2000, Dec 9,279(1):219-22.
  DOI: 10.1006/bbrc.2000.3906
  pubMed: 11112442

• Isolation of callipeltins A-C and of two new open-chain derivatives of callipeltin A from the marine sponge Latrunculia sp. A revision of the stereostructure of callipeltins
  Trevisi L, D Auria MV, Luciani S, Zampella A, Debitus C, Randazzo A, Borbone N, Tetrahedron letters , 2002, 43 (35), pp. 6163-6166
  

• Solid-phase synthesis and configurational reassigment of callipeltin E. Implications for the structures of callipeltins A and B
  Calimsiz S, Morales Ramos AI, Lipton MA, The Journal of organic chemistry , 2006, 18,71(17):6351-6.
  DOI: 10.1021/jo060351h
  pubMed: 16901115

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