actinomycin II
- Norine ID: NOR00230
- DOI: 10.26097/nor00230
- Family: actinomycin
- Synonym(s): actinomycin II;
- Activity: antimicrobial
- Category: chromopeptide
- Formula: C58H82N12O16
- Monoisotopic mass: 1202.597174636 g/mol
- Comment: If sarcosine is added to the medium, the micro-organism produces, in addition to actinomycins D and I, actinomycin II and actinomycin III, characterized by the substitution by sarcosine of one or both the proline molecules present in actinomycin D.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: double cyclic
- Number of monomers: 11
- Smiles: CC(C)C5NC(=O)C(NC(=O)c2ccc(C)c3OC4=C(C)C(=O)C(N)=C(C(=O)NC1C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)CN(C)C(=O)C(NC1(=O))C(C)C)C4(=Nc23))C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)CN(C)C5(=O)
- Graph inference:
- Monomeric composition :
1 D-Val 2 NMe-Gly 3 NMe-Gly 4 NMe-Val 5 Thr 6 ChrAct 7 Thr 8 D-Val 9 NMe-Gly 10 NMe-Gly 11 NMe-Val - Graph representation: D-Val,NMe-Gly,NMe-Gly,NMe-Val,Thr,ChrAct,Thr,D-Val,NMe-Gly,NMe-Gly,NMe-Val @1,4 @0,2 @1,3 @2,4 @0,3,5 @4,6 @5,7,10 @6,8 @7,9 @8,10 @6,9
- Atomic structure:
- Streptomyces antibioticus
- gram: positive
- synonyms: Actinomyces antibioticus
- taxid: 1890 (view NCBI taxonomy browser)
- Streptomyces chrysomallus
- gram: positive
- synonyms: Streptomyces anulatus,Streptomyces fluorescens,Streptomyces citreofluorescens,Actinomyces fluorescens,Actinomyces citreofluorescens,Actinomyces annulatus,Actinomyces Streptothrix annulatus
- taxid: 1892 (view NCBI taxonomy browser)
- Streptomyces sp.
- gram: positive
- synonyms:
- taxid: 1931 (view NCBI taxonomy browser)
- Links between organisms producing the actinomycin II: Streptomyces antibioticus, Streptomyces chrysomallus, Streptomyces sp.
- The isolation and structure of actinomycins II and III
JOHNSON AW, MAUGER AB, The Biochemical journal , 1959, Nov,73:535-8.
DOI: 10.1042/bj0730535
pubMed: 14407419
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