Norine

• Norine ID: NOR00232
• DOI: 10.26097/nor00232
• Family: actinomycin
• Synonym(s): actinomycin V;
• Activity: antimicrobial
• Category: chromopeptide
• Formula: C62H84N12O17
• Monoisotopic mass: 1268.6077393219998 g/mol
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: double cyclic
• Number of monomers: 11
• Smiles: CC(C)C6NC(=O)C(NC(=O)c3ccc(C)c4OC5=C(C)C(=O)C(N)=C(C(=O)NC1C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CC(=O)CN2(C(=O)C(NC1(=O))C(C)C))C5(=Nc34))C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C7CCCN7(C6(=O))
  
  
• Graph inference:


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• Monomeric composition and PDB SEQRES:

  1 Thr 1 THR

  2 D-Val 2 DVA

  3 4oxo-Pro 3 DPL

  4 NMe-Gly 4 SAR

  5 NMe-Val 5 MVA

  6 ChrAct 6 PXZ

  7 Thr 7 THR

  8 D-Val 8 DVA

  9 Pro 9 PRO

  10 NMe-Gly 10 SAR

  11 NMe-Val 11 MVA

• Graph representation: Thr,D-Val,4oxo-Pro,NMe-Gly,NMe-Val,ChrAct,Thr,D-Val,Pro,NMe-Gly,NMe-Val @1,4,5 @0,2 @1,3 @2,4 @3,0 @0,6 @5,7,10 @6,8 @7,9 @8,10 @6,9
  
  
• Atomic structure:

vizualisation:

• Streptomyces antibioticus
• gram: positive
• synonyms: Actinomyces antibioticus
• taxid: 1890 (view NCBI taxonomy browser)

• Streptomyces sp.
• gram: positive
• synonyms:
• taxid: 1931 (view NCBI taxonomy browser)

• Links between organisms producing the actinomycin V: Streptomyces antibioticus, Streptomyces sp.

• Isolation and identification of oxoproline in actinomycin X2. (V). Hydrolysates
  Diegelmann R, Mauger A, Katz E, The Journal of antibiotics , 1969, Feb,22(2):85-7.
  DOI: 10.7164/antibiotics.22.85
  pubMed: 4181575

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