Norine

• Norine ID: NOR00825
• DOI: 10.26097/nor00825
• Family: nodularin
• Synonym(s): motuporin;
• Activity: toxin
• Category: PK-NRP
• Formula: C40H63N5O10
• Monoisotopic mass: 773.4574932609999 g/mol
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: cyclic
• Number of monomers: 5
• Smiles: C/C=C\1/C(=O)N[C@H]([C@@H](C(=O)N[C@H](C(=O)N[C@H]([C@@H](C(=O)N[C@H](CCC(=O)N1C)C(=O)O)C)/C=C/C(=C/[C@H](C)[C@H](CC2=CC=CC=C2)OC)/C)C(C)C)C)C(=O)O
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 D-bMe-Asp

  2 Val

  3 Adda

  4 D-Glu

  5 2Dh-Mabu

• Graph representation: D-bMe-Asp,Val,Adda,D-Glu,2Dh-Mabu @1,4 @0,2 @1,3 @2,4 @0,3
  
  
• Atomic structure:

vizualisation:

• Theonella swinhoei
• taxid: 37505 (view NCBI taxonomy browser)

• Links between organisms producing the motuporin: Theonella swinhoei

• Motuporin, a potent protein phosphatase inhibitor isolated from the Papua New Guinea sponge Theonella swinhoei gray
  Williams DE, Holmes CFB, Andersen RJ, De Silva ED, Allen TM, KLIX H, Tetrahedron letters , 1992, vol. 33, no12, pp. 1561-1564
  

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