Val-gramicidin A
- Norine ID: NOR00243
- DOI: 10.26097/nor00243
- Family: gramicidin
- Synonym(s): gramicidin D;
- Activity: antimicrobial
- Category: peptide
- Formula: C99H140N20O17
- Monoisotopic mass: 1881.070533154 g/mol
- Comment: Gramicidin is a heterogeneous mixture of six antibiotic compounds divided into three catagories: Gramicidin A, B and C, all of which are obtained from the soil bacterial species Bacillus brevis and called collectively Gramicidin D. Gramicidin is active against Gram-positive organisms,except for the Gram-positive bacilli, and against certain Gram-negative organisms, such as Neisseria.Gramicidin A is a naturally-occurring ion channel-forming pentadecapeptide. The association of two gramicidin A peptides causes the formation of a monovalent cation-selective ion channel.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: linear
- Number of monomers: 16
- Smiles: CC(C)CC(C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC(C)C)C(=O)NC(CC5=CNC6=CC=CC=C65)C(=O)NC(CC(C)C)C(=O)NC(CC7=CNC8=CC=CC=C87)C(=O)NCCO)NC(=O)C(C)NC(=O)CNC(=O)C(C(C)C)NC=O
- Graph inference:
- Monomeric composition and PDB SEQRES:
1 NFo-Val 1 2 For Val gra2 Gly 3 GLY 3 Ala 4 ALA 4 5 D-Leu Ala 5 D-Leu 6 7 D-Val Val 6 Ala 8 9 D-Val Trp 7 D-Val 10 11 D-Leu Trp 8 Val 12 13 D-Leu Trp 9 D-Val 14 15 D-Leu Trp 10 Trp 16 Eta 11 ETA - Graph representation: NFo-Val,Gly,Ala,D-Leu,Ala,D-Val,Val,D-Val,Trp,D-Leu,Trp,D-Leu,Trp,D-Leu,Trp,Eta @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11,13 @12,14 @13,15 @14
- Atomic structure:
- Bacillus brevis
- gram: positive
- synonyms: Brevibacillus brevis
- taxid: 1393 (view NCBI taxonomy browser)
- Links between organisms producing the Val-gramicidin A: Bacillus brevis
- Structure elucidation of four related substances in gramicidin with liquid chromatography/mass spectrometry
Govaerts C, Orwa J, Van Schepdael A, Roets E, Hoogmartens J, Rapid communications in mass spectrometry : RCM , 2001, 15(2):128-34.
DOI: 10.1002/1097-0231(20010130)15:2<128::AID-RCM205>3.0.CO;2-O
pubMed: 11180541
- The linear pentadecapeptide gramicidin is assembled by four multimodular nonribosomal peptide synthetases that comprise 16 modules with 56 catalytic domains
Marahiel MA, Kessler N, Schuhmann H, Morneweg S, Linne U, The Journal of biological chemistry , 2004, Feb 27,279(9):7413-9.
DOI: 10.1074/jbc.M309658200
pubMed: 14670971
Q70LM7
Q70LM6
Q70LM5
Q70LM4
16130140 16132269
CHEMBL601118
3l8l 1av2 1c4d 2izq 1w5u 1al4 1alx 3zq8 2y5m 2y6n 2xdc 1nrm 1nru 1jno 1bdw 1gmk 1alz 1mic 1mag 1grm
3l8l 1av2 1c4d 2izq 1w5u 1al4 1alx 3zq8 2y5m 2y6n 2xdc 1nrm 1nru 1jno 1bdw 1gmk 1alz 1mic 1mag 1grm
3l8l 1av2 1c4d 2izq 1w5u 1al4 1alx 3zq8 2y5m 2y6n 2xdc 1nrm 1nru 1jno 1bdw 1gmk 1alz 1mic 1mag 1grm
16130140 16132269
CHEMBL601118
3l8l 1av2 1c4d 2izq 1w5u 1al4 1alx 3zq8 2y5m 2y6n 2xdc 1nrm 1nru 1jno 1bdw 1gmk 1alz 1mic 1mag 1grm
3l8l 1av2 1c4d 2izq 1w5u 1al4 1alx 3zq8 2y5m 2y6n 2xdc 1nrm 1nru 1jno 1bdw 1gmk 1alz 1mic 1mag 1grm
3l8l 1av2 1c4d 2izq 1w5u 1al4 1alx 3zq8 2y5m 2y6n 2xdc 1nrm 1nru 1jno 1bdw 1gmk 1alz 1mic 1mag 1grm
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