Norine

• Norine ID: NOR01255
• DOI: 10.26097/nor01255
• Family: Orfamide
• Synonym(s): Orfamide A;
• Activity: antimicrobial, surfactant
• Category: lipopeptide
• Formula: C64H114N10O17
• Monoisotopic mass: 1294.836342272 g/mol
• Comment:
• Source: mynorine
• Contributor (creation): Valerie Leclere [Charles Viollette Institute, ProBioGEM team, Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2022-09-07 by Matthieu Duban [UMR BioEcoAgro 1158 ICV]
  • view all entry history

• Type: partial cyclic
• Number of monomers: 11
• Smiles: CCCCCCCCCCCC(CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H]1[C@@H](OC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC1=O)[C@H](C)CC)CC(C)C)CO)CC(C)C)CC(C)C)CO)C(C)C)C)O
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 Leu

  2 Leu

  3 Leu

  4 D-Glu

  5 D-aThr

  6 D-aIle

  7 C14:0-OH(3)

  8 D-Ser

  9 Leu

  10 D-Ser

  11 Val

• Graph representation: Leu,Leu,Leu,D-Glu,D-aThr,D-aIle,C14:0-OH(3),D-Ser,Leu,D-Ser,Val @3,6 @7,8 @5,7 @0,4 @3,5,10 @2,4 @0 @1,2 @1,9 @8,10 @4,9
  
  
• Atomic structure:

vizualisation:

• Pseudomonas fluorescens Pf-5
• gram: negative
• synonyms:
• taxid: 220664 (view NCBI taxonomy browser)

• Links between organisms producing the Orfamide A: Pseudomonas fluorescens Pf-5

• The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters
  Loper JE, Gross H, Stockwell VO, Henkels MD, Nowak-Thompson, ChemBiol , 2007, 14; 53-63
  pubMed: 17254952

  Q4KET1 Q4KET0 Q4KES9

  102456656

  BGC0000399