alamethicin F30
- Norine ID: NOR00010
- DOI: 10.26097/nor00010
- Family: alamethicin
- Synonym(s): alamethicin F30;
- Activity: antimicrobial
- Category: peptaibol
- Formula: C92H150N22O26
- Monoisotopic mass: 1979.1091630820001 g/mol
- Comment: The natural alpha-helical peptide antibiotic alamethicin forms voltage-gated ion channels in lipid membranes.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: linear
- Number of monomers: 20
- Smiles: C[C@H](C(=O)N[C@H](CCC(=O)N)C(=O)NC(C)(C)C(=O)N[C@H](C(C)C)C(=O)NC(C)(C)C(=O)NCC(=O)N[C@H](CC(C)C)C(=O)NC(C)(C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](CCC(=O)N)C(=O)N[C@H](CC2=CC=CC=C2)CO)NC(=O)C(C)(C)NC(=O)[C@@H](C)NC(=O)C(C)(C)NC(=O)[C@H]3CCCN3C(=O)C(C)(C)NC(=O)C
- Graph inference:
- Monomeric composition and PDB SEQRES:
1 Ac-Aib 1 2 ACE AIB gra2 Pro 3 PRO 3 Aib 4 AIB 4 Ala 5 ALA 5 Aib 6 AIB 6 Ala 7 ALA 7 Gln 8 GLN 8 Aib 9 AIB 9 Val 10 VAL 10 Aib 11 AIB 11 Gly 12 GLY 12 Leu 13 LEU 13 Aib 14 AIB 14 Pro 15 PRO 15 Val 16 VAL 16 Aib 17 AIB 17 Aib 18 AIB 18 Glu 19 GLU 19 Gln 20 GLN 20 Pheol 21 PHL - Graph representation: Ac-Aib,Pro,Aib,Ala,Aib,Ala,Gln,Aib,Val,Aib,Gly,Leu,Aib,Pro,Val,Aib,Aib,Glu,Gln,Pheol @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11,13 @12,14 @13,15 @14,16 @15,17 @16,18 @17,19 @18
- Atomic structure:
- Trichoderma viride
- synonyms: Trichoderma lignorum
- taxid: 5547 (view NCBI taxonomy browser)
- Links between organisms producing the alamethicin F30: Trichoderma viride
- Analysis of the lipophilic peptaibol alamethicin by nonaqueous capillary electrophoresis-electrospray ionization-mass spectrometry
Psurek A, Neususs C, Pelzing M, Scriba GK, Electrophoresis , 2005, Nov,26(22):4368-78.
DOI: 10.1002/elps.200500387
pubMed: 16287177
Return to annotations search