Norine

• Norine ID: NOR00702
• DOI: 10.26097/nor00702
• Family: orienticin
• Synonym(s): orienticin A;
• Activity: antimicrobial
• Category: glycopeptide
• Formula: C73H89ClN10O26
• Monoisotopic mass: 1556.5638007799998 g/mol
• Comment: Two bonds of the central Hpg are due to oxidative ring closure.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: other
• Number of monomers: 10
• Smiles: CNC(CC(C)C)C(=O)NC2C(=O)NC(CC(N)=O)C(=O)NC8c5cc(Oc1ccc(cc1)C2(O))c(OC4OC(CO)C(O)C(O)C4(OC3CC(C)(N)C(O)C(C)O3))c(c5)Oc6ccc(cc6Cl)C(OC7CC(C)(N)C(O)C(C)O7)C%10NC(=O)C(NC8(=O))c9ccc(O)c(c9)c%11c(O)cc(O)cc%11(C(NC%10(=O))C(=O)O)
  
  
• Graph inference:


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• Monomeric composition :

  1 Asn

  2 bOH-Tyr

  3 NMe-Leu

  4 Hpg

  5 D-Glc

  6 Ere

  7 bOH-Cl-Tyr

  8 Ere

  9 Dhpg

  10 Hpg

• Graph representation: Asn,bOH-Tyr,NMe-Leu,Hpg,D-Glc,Ere,bOH-Cl-Tyr,Ere,Dhpg,Hpg @1,3 @0,2,3 @1 @1,0,4,6,9 @3,5 @4 @3,8,7,9 @6 @6,9 @8,3,6
  
  
• Atomic structure:

vizualisation:

• Nocardia orientalis
• gram: positive
• synonyms: Amycolatopsis orientalis,Streptomyces orientalis,Amycolatopsis orientalis orientalis
• taxid: 31958 (view NCBI taxonomy browser)

• Links between organisms producing the orienticin A: Nocardia orientalis

• New glycopeptide antibiotics. I. The structures of orienticins
  Kobayashi M, Yoshimura Y, Tsuji N, Kamigauchi T, Terui Y, The Journal of antibiotics , 1988, Jun,41(6):819-22.
  DOI: 10.7164/antibiotics.41.819
  pubMed: 3403380

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