Norine

• Norine ID: NOR00038
• DOI: 10.26097/nor00038
• Family: cyclosporin
• Synonym(s): cyclosporin F;
• Activity: unknown
• Category: peptide
• Formula: C63H113N11O11
• Monoisotopic mass: 1199.862103513 g/mol
• Comment: Natural analogs of cyclosporin A are obtain in different nutrient broths
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: cyclic
• Number of monomers: 11
• Smiles: CCCC1NC(=O)C(CC(C)CC=CC)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 Ala

  2 Val

  3 NMe-Leu

  4 NMe-Val

  5 NMe-Leu

  6 NMe-Leu

  7 Nva

  8 Ala

  9 NMe-Leu

  10 NMe-Gly

  11 3d-NMe-Bmt

• Graph representation: Ala,Val,NMe-Leu,NMe-Val,NMe-Leu,NMe-Leu,Nva,Ala,NMe-Leu,NMe-Gly,3d-NMe-Bmt @8,7 @2,5 @1,7 @10,4 @3,8 @1,9 @10,9 @0,2 @0,4 @5,6 @3,6
  
  
• Atomic structure:

vizualisation:

• Tolypocladium inflatum
• gram:
• synonyms:
• taxid: 1086729 (view NCBI taxonomy browser)

• Links between organisms producing the cyclosporin F: Tolypocladium inflatum

• Multifunctional Peptide Synthetases
  von Dohren H, Keller U, Vater J, Zocher R, Chemical reviews , 1997, Nov 10,97(7):2675-2706.
  pubMed: 11851477

  Q09164