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apicidin


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  • Norine ID: NOR01107
  • DOI: 10.26097/nor01107
  • Family: apicidin
  • Synonym(s): apicidin;
  • Activity: antitumor, toxin
  • Category: peptide
  • Formula: C34H49N5O6
  • Monoisotopic mass: 623.368284325 g/mol
  • Source: norine
  • Contributor (creation): Jin Jm
  • Entry information:
  • Type: cyclic
  • Number of monomers: 4
  • Smiles: CCC(=O)CCCCCC3NC(=O)C4CCCCN4(C(=O)C(NC(=O)C(Cc1cn(OC)c2ccccc12)NC3(=O))C(C)CC)

  • Graph inference:



  • Monomeric composition :
    1
    C10:0-NH2(2)-oxo(8)
    2
    D-Hpr
    3
    Ile
    4
    OMe-Trp
  • Graph representation: C10:0-NH2(2)-oxo(8),D-Hpr,Ile,OMe-Trp @1,3 @0,2 @1,3 @0,2

  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Fusarium
  • gram:
  • synonyms:
  • taxid: 5506 (view NCBI taxonomy browser)

  • Links between organisms producing the apicidin: Fusarium
  • Structure and chemistry of apicidins, a class of novel cyclic tetrapeptides without a terminal alpha-keto epoxide as inhibitors of histone deacetylase with potent antiprotozoal activities
    Singh SB, Zink DL, Liesch JM, Mosley RT, Dombrowski AW, Bills GF, Darkin-Rattray SJ, Schmatz DM, Goetz MA, The Journal of organic chemistry , 2002, Feb 8,67(3):815-25.
    DOI: 10.1021/jo016088w
    pubMed: 11856024
  • Purification and Phytotoxicity of Apicidins Produced by the Fusarium semitectum KCTC16676
    Jin JM, Baek SR, Lee KR, Lee JK, Yun SH, KangS, Lee YW, The Plant Pathology Journal , 2008, vol 24, No 4, pp. 417-422.


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