moiramide B
- Norine ID: NOR00727
- DOI: 10.26097/nor00727
- Family: andrimid
- Synonym(s): moiramide B;
- Activity: antimicrobial
- Category: PK-NRP
- Formula: C25H31N3O5
- Monoisotopic mass: 453.226371117 g/mol
- Comment: The pseudopeptide pyrrolidinedione natural products moiramide B and andrimid represent a new class of antibiotics that target bacterial fatty acid biosynthesis.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: linear
- Number of monomers: 4
- Smiles: CC=CC=CC(=O)NC(CC(=O)NC(C(C)C)C(=O)C1C(=O)NC(=O)C1(C))c2ccccc2
- Graph inference:
- Monomeric composition :
1 C6:2(t2.t4) 2 D-bPhe 3 Val 4 Me-Suc - Graph representation: C6:2(t2.t4),D-bPhe,Val,Me-Suc @1 @0,2 @1,3 @2
- Atomic structure:
- Enterobacter
- synonyms: Aerobacter,Cloaca
- taxid: 547 (view NCBI taxonomy browser)
- Vibrio
- synonyms: Microspira,Pacinia
- taxid: 662 (view NCBI taxonomy browser)
- Pseudomonas
- gram: negative
- synonyms:
- taxid: 286 (view NCBI taxonomy browser)
- Links between organisms producing the moiramide B: Enterobacter, Vibrio, Pseudomonas
- A biosynthetic gene cluster for the acetyl-CoA carboxylase inhibitor andrimid
Jin M, Fischbach MA, Clardy J, Journal of the American Chemical Society , 2006, Aug 23,128(33):10660-1.
DOI: 10.1021/ja063194c
pubMed: 16910643
- Pyrrolidinedione derivatives as antibacterial agents with a novel mode of action
Pohlmann J, Lampe T, Shimada M, Nell PG, Pernerstorfer J, Svenstrup N, Brunner NA, Schiffer G, Freiberg C, Bioorganic and medicinal chemistry letters , 2005, 15,15(4):1189-92.
DOI: 10.1016/j.bmcl.2004.12.002
pubMed: 15686939
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