alamethicin F50
- Norine ID: NOR00007
- DOI: 10.26097/nor00007
- Family: alamethicin
- Synonym(s): alamethicin F50;
- Activity: antimicrobial
- Category: peptaibol
- Formula: C92H151N23O24
- Monoisotopic mass: 1962.130232875 g/mol
- Comment: The natural alpha-helical peptide antibiotic alamethicin forms voltage-gated ion channels in lipid membranes.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: linear
- Number of monomers: 20
- Smiles: CC(C)CC(NC(=O)CNC(=O)C(C)(C)NC(=O)C(NC(=O)C(C)(C)NC(=O)C(CCC(N)=O)NC(=O)C(C)NC(=O)C(C)(C)NC(=O)C(C)NC(=O)C(C)(C)NC(=O)C1CCCN1C(=O)C(C)(C)NC(C)=O)C(C)C)C(=O)NC(C)(C)C(=O)N3CCCC3(C(=O)NC(C(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NC(CCC(N)=O)C(=O)NC(CCC(N)=O)C(=O)NC(CO)Cc2ccccc2)
- Graph inference:
- Monomeric composition :
1 Ac-Aib 2 Pro 3 Aib 4 Ala 5 Aib 6 Ala 7 Gln 8 Aib 9 Val 10 Aib 11 Gly 12 Leu 13 Aib 14 Pro 15 Val 16 Aib 17 Aib 18 Gln 19 Gln 20 Pheol - Graph representation: Ac-Aib,Pro,Aib,Ala,Aib,Ala,Gln,Aib,Val,Aib,Gly,Leu,Aib,Pro,Val,Aib,Aib,Gln,Gln,Pheol @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11,13 @12,14 @13,15 @14,16 @15,17 @16,18 @17,19 @18
- Atomic structure:
- Trichoderma viride
- synonyms: Trichoderma lignorum
- taxid: 5547 (view NCBI taxonomy browser)
- Links between organisms producing the alamethicin F50: Trichoderma viride
- Analysis of the lipophilic peptaibol alamethicin by nonaqueous capillary electrophoresis-electrospray ionization-mass spectrometry
Psurek A, Neususs C, Pelzing M, Scriba GK, Electrophoresis , 2005, Nov,26(22):4368-78.
DOI: 10.1002/elps.200500387
pubMed: 16287177
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