Norine

• Norine ID: NOR00678
• DOI: 10.26097/nor00678
• Family: pristinamycin I
• Synonym(s): pristinamycin IC;
• Activity: antimicrobial
• Category: peptide
• Formula: C44H52N8O10
• Monoisotopic mass: 852.380639924 g/mol
• Comment: Pristinamycins I are members of the streptogramin B group.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: partial cyclic
• Number of monomers: 7
• Smiles: CC3NC(=O)C(NC(=O)c1ncccc1(O))C(C)OC(=O)C(NC(=O)C5CC(=O)CCN5(C(=O)C(Cc2ccc(cc2)N(C)C)N(C)C(=O)C4CCCN4(C3(=O))))c6ccccc6
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 Hpa

  2 Thr

  3 D-Ala

  4 Pro

  5 NMe-Me2A-Phe

  6 4oxo-Hpr

  7 Ph-Gly

• Graph representation: Hpa,Thr,D-Ala,Pro,NMe-Me2A-Phe,4oxo-Hpr,Ph-Gly @1 @0,2,6 @1,3 @2,4 @3,5 @4,6 @1,5
  
  
• Atomic structure:

vizualisation:

• Streptomyces
• gram: positive
• synonyms: Chainia
• taxid: 1883 (view NCBI taxonomy browser)

• Links between organisms producing the pristinamycin IC: Streptomyces

• Streptogramin B biosynthesis in Streptomyces pristinaespiralis and Streptomyces virginiae: molecular characterization of the last structural peptide synthetase gene
  de Crecy-Lagard V, Saurin W, Thibaut D, Gil P, Naudin L, Crouzet J, Blanc V, Antimicrobial agents and chemotherapy , 1997, Sep,41(9):1904-9.
  pubMed: 9303382

  P95819 Q54959 O07944

  443310