Norine

• Norine ID: NOR00231
• DOI: 10.26097/nor00231
• Family: actinomycin
• Synonym(s): actinomycin III;
• Activity: antimicrobial
• Category: chromopeptide
• Formula: C60H88N12O18
• Monoisotopic mass: 1264.6339540719998 g/mol
• Comment: If sarcosine is added to the medium, the micro-organism produces, in addition to actinomycins D and I, actinomycin II and actinomycin III, characterized by the substitution by sarcosine of one or both the proline molecules present in actinomycin D.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: double cyclic
• Number of monomers: 11
• Smiles: CC(C)C6NC(=O)C(NC(=O)C4=C(N)C(=O)C(C)=C3Oc5c(C)ccc(C(=O)NC1C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2(C(=O)C(NC1(=O))C(C)C))c5(N=C34))C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)CN(C)C6(=O)
  
  
• Graph inference:


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• Monomeric composition :

  1 D-Val

  2 NMe-Gly

  3 NMe-Gly

  4 NMe-Val

  5 Thr

  6 ChrAct

  7 Thr

  8 D-Val

  9 Pro

  10 NMe-Gly

  11 NMe-Val

• Graph representation: D-Val,NMe-Gly,NMe-Gly,NMe-Val,Thr,ChrAct,Thr,D-Val,Pro,NMe-Gly,NMe-Val @1,4 @0,2 @1,3 @2,4 @0,3,5 @4,6 @5,7,10 @6,8 @7,9 @8,10 @6,9
  
  
• Atomic structure:

vizualisation:

• Streptomyces antibioticus
• gram: positive
• synonyms: Actinomyces antibioticus
• taxid: 1890 (view NCBI taxonomy browser)

• Streptomyces chrysomallus
• gram: positive
• synonyms: Streptomyces anulatus,Streptomyces fluorescens,Streptomyces citreofluorescens,Actinomyces fluorescens,Actinomyces citreofluorescens,Actinomyces annulatus,Actinomyces Streptothrix annulatus
• taxid: 1892 (view NCBI taxonomy browser)

• Streptomyces sp.
• gram: positive
• synonyms:
• taxid: 1931 (view NCBI taxonomy browser)

• Links between organisms producing the actinomycin III: Streptomyces antibioticus, Streptomyces chrysomallus, Streptomyces sp.

• The isolation and structure of actinomycins II and III
  JOHNSON AW, MAUGER AB, The Biochemical journal , 1959, Nov,73:535-8.
  DOI: 10.1042/bj0730535
  pubMed: 14407419

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