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discodermin A


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  • Norine ID: NOR00447
  • DOI: 10.26097/nor00447
  • Family: discodermin
  • Synonym(s): discodermin A;
  • Activity: antitumor, antibiotic, toxin
  • Class: peptide
  • Formula: C77H115N20O22S
  • Monoisotopic mass: 1703.8215511639999 g/mol
  • Comment: Discodermin A is a putative NRPS product (no synthetase genes identified).
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: putative
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: partial cyclic
  • Number of monomers: 14
  • Smiles: CC(C)CC1NC(=O)C(CCC(N)=O)N(C)C(=O)C(NC(=O)C(CS(O)(=O)=O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC2=CNC3=CC=CC=C23)NC(=O)C(NC(=O)C(NC(=O)C2CCCN2C(=O)C(CC2=CC=CC=C2)NC(=O)C(C)NC=O)C(C)(C)C)C(C)(C)C)C(C)OC(=O)CN(C)C(=O)C(CC(N)=O)NC(=O)C(NC1=O)C(C)O

  • Graph inference:



  • Monomeric composition :
    1
    D-NFo-Ala
    2
    Phe
    3
    Pro
    4
    D-t-Leu
    5
    t-Leu
    6
    D-Trp
    7
    Arg
    8
    D-CysA
    9
    Thr
    10
    NMe-Gln
    11
    D-Leu
    12
    Thr
    13
    Asn
    14
    NMe-Gly
  • Graph representation: D-NFo-Ala,Phe,Pro,D-t-Leu,t-Leu,D-Trp,Arg,D-CysA,Thr,NMe-Gln,D-Leu,Thr,Asn,NMe-Gly @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9,13 @8,10 @9,11 @10,12 @11,13 @8,12

  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Discodermia kiiensis
  • gram:
  • synonyms:
  • taxid: (view NCBI taxonomy browser)

  • Links between organisms producing the discodermin A: Discodermia kiiensis
  • Membrane permeabilization induced by discodermin A, a novel marine bioactive peptide
    Matsunaga S, Fusetani N, Sato K, Horibe K, Amano K, Mitusi-Saito M, Hori M, Ozaki H, Karaki H, Toxicon : official journal of the International Society on Toxinology , 2001, Feb-Mar,39(2-3):259-64.
    DOI: 10.1016/s0041-0101(00)00123-9
    pubMed: 10978743


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