Norine

• Norine ID: NOR00637
• DOI: 10.26097/nor00637
• Family: tuberactinomycin
• Synonym(s): tuberactinamine;
• Activity: antimicrobial
• Category: peptide
• Formula: C19H31N11O8
• Monoisotopic mass: 541.2357070229999 g/mol
• Comment: The tuberactinomycin antibiotics are essential components in the drug arsenal against Mycobacterium tuberculosis infections and are specifically used for the treatment of multidrug-resistant tuberculosis.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: cyclic
• Number of monomers: 5
• Smiles: NC(=O)NC=C1NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(N)CNC(=O)C(NC1(=O))C2CCN=C(N)N2
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 Dpr

  2 Ser

  3 Ser

  4 bU-dAla

  5 Cap

• Graph representation: Dpr,Ser,Ser,bU-dAla,Cap @1,4 @0,2 @1,3 @2,4 @0,3
  
  
• Atomic structure:

vizualisation:

• Streptomyces
• gram: positive
• synonyms: Chainia
• taxid: 1883 (view NCBI taxonomy browser)

• Links between organisms producing the tuberactinamine: Streptomyces

• Deciphering tuberactinomycin biosynthesis: isolation, sequencing, and annotation of the viomycin biosynthetic gene cluster
  Thomas MG, Chan YA, Ozanick SG, Antimicrobial agents and chemotherapy , 2003, Sep,47(9):2823-30.
  DOI: 10.1128/aac.47.9.2823-2830.2003
  pubMed: 12936980

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