YASS :: genomic similarity search tool

What is YASS ?

YASS is a genomic similarity search tool, for nucleic (DNA/RNA) sequences in fasta or plain text format (it produces local pairwise alignments). Like most of the heuristic pairwise local alignment tools for DNA sequences (FASTA, BLAST, PATTERNHUNTER, BLASTZ/LASTZ, LAST ...), YASS uses seeds to detect potential similarity regions, and then tries to extend them to local alignments. This genomic search tool uses multiple transition constrained spaced seeds that enable to search more fuzzy repeats, as non-coding DNA/RNA. Another simple, but interesting feature is that you can specify the seed pattern used in the search step (as provided for example by iedera).

Main features of YASS are:

• multiple, possibly overlapping seeds and a new hit criterion to ensure a good sensitivity/selectivity trade-off
• transition-constrained spaced seeds to improve sensitivity (transition mutations are purine to purine [A↔G] or pyrimidine to pyrimidine [C↔T])
• using different scoring schemes with bit-score and E-value evaluated according to the sequence background frequencies
• parameterizable output filter for low complexity repeats
• reporting of various alignment statistical parameters (mutation bias along triplets, transition/transversion)
• post-processing step to group gapped alignments

YASS produces the common blast tabular output files ("-d 3" option). Moreover, a small perl script is provided to transform the original extended output ("-d 1" option) into blast output with alignments (which can be directly parsed with Bioperl), axt files, or fasta alignments : yass2blast.pl. Another small php script is provided to transform the original extended output ("-d 1" option) into png dotplot files : yass2dotplot.php.

If you use this program in your work, please cite :

[1]    L. Noe, G. Kucherov YASS: enhancing the sensitivity of DNA similarity search, 2005, Nucleic Acids Research, 33(2):W540-W543.

Of course, your are welcome and always appreciated!

Query YASS Online

You can query YASS from this server: yass.php.

The web interface enables you to run the YASS pairwise alignment tool online, on your DNA sequences, and visualise the pairwise local alignments produced online:

• paste or upload your genomic sequences, or use the proposed ones,
• control several of the YASS parameters, from selecting the E-value or refining the scoring system, to selecting the (transition) spaced seed model,
• produce a dot-plot view of the alignments / a tabular view of the complete output,
• download the result as a yass/blast/axt/fasta output file,
• run an annotation Blast, a multiple alignment Clustalw of Muscle, or Mfold, on a simple click.

Publications

A non-exhaustive list of papers that use YASS ... I also try to maintain a (try to be) exhaustive list of "spaced seeds" related papers for those interested in this subject. Please let me know if I forget someone ...

• A macroevolutionary role for chromosomal fusion and fission in Erebia butterflies - YASS was used to map contigs to the Barcode of Life Database.
• The fifth international hackathon for developing computational cloud-based tools and resources for pan-structural variation and genomics - YASS was used in the SalsaValentina pipeline.
• Avirulent UG10 Entamoeba histolytica mutant derived from HM-1:IMSS strain shows limited genome variability and aberrant 5-methyl cytosine genomic distribution - YASS was used in a graphical comparison of the filtered and assembled reads of UG10.
• An endogenous DNA virus in an amphibian-killing fungus associated with pathogen genotype and virulence - YASS was used to compare the putative viral contig.
• Extreme genome scrambling in marine planktonic Oikopleura dioica cryptic species - YASS seeds were used in the LAST software to align query/target genomes.
• PerFSeeB: designing long high-weight single spaced seeds for full sensitivity alignment with a given number of mismatches - YASS seeds were shown in the non-binary set context.
• Comparative genomic analysis of Lactobacillus crispatus strains Lc31 andLc83withanti-cervical cancer potential by complete genome sequencing - pairwise whole-genome dot-plots were created using YASS.
• Local Genomic Instability of the SpTransformer Gene Family in the Purple Sea Urchin Inferred from BAC Insert Deletions - Dot plots were generated using the YASS genomic similarity search tool.
• Telomere sequence variability in genotypes from natural plant populations: unusual block-organized double-monomer terminal telomeric arrays - Self-to-self comparisons of the ON reads displayed as dot plots with YASS.
• Unique repetitive nucleic acid structures mirror switch regions in the human IgH locus - Ig sequences were searched for direct or inverted repeats using the YASS similarity search algorithm.
• De novo transcriptome assembly of mouse male germ cells reveals novel genes, stage-specific bidirectional promoter activity, and noncoding RNA expression - Self-similarity of a region on Chromosome 8 was determined using YASS to identify local alignments.
• Subtelomeric 5-enolpyruvylshikimate-3-phosphate synthase copy number variation confers glyphosate resistance in Eleusine indica - Contigs of interest were self-aligned in YASS.
• Conservation of the Restricted Expression of Brassicaceae Bsister-Like Genes in Seeds Requires a Transposable Element in Arabidopsis thaliana - Dot plots were generated using Yass.
• A high-quality reference genome for the fission yeast Schizosaccharomyces osmophilus - YASS was used to identify Centromeric repeats.
• Reorganization of the ancestral sex-determining regions during the evolution of trioecy in Pleodorina starrii - ().
• Long-Term Balancing Selection and the Genetic Load Linked to the Self-Incompatibility Locus in Arabidopsis halleri and A. lyrata - YASS was used to identify orthologous regions along the A. lyrata genome.
• Chromosome-level genome assembly of Babesia caballi reveals diversity of multigene families among Babesia species - Apicoplast genome was visualized by YASS.
• Whole genome sequence and diversity in multigene families of Babesia ovis - YASS was used to examine Structural diversity among apicoplast genomes of B. ovis, B. bovis, and Babesia sp. Xinjiang.
• Detection of trait-associated structural variations using short-read sequencing - YASS was used to align INS sequences to the Alu, L1, and SVA reference sequences.
• Expanded male sex-determining region conserved during the evolution of homothallism in the green alga Volvox - YASS was used to perform dotplot analyses between contig022 of V. africanus TH and V. reticuliferus male SDR.
• Global dissection of R2R3-MYB in Pogostemon cablin uncovers a species-specific R2R3-MYB clade - YASS was used to display tandem duplicated genes.
• Can avian flyways reflect dispersal barriers of clinostomid parasites? First evidence from the mitogenome of Clinostomum complanatum - YASS was used, where ?
• Chromosome-dependent aneuploid formation in Spo11-less meiosis - YASS was used to detect SNPs and InDels.
• Target enrichment of long open reading frames and ultraconserved elements to link microevolution and macroevolution in non‐model organisms - YASS was used to screen the Unioverse loci against the BUSCO Metazoa_odb9 database.
• Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in the acute inflammatory phase of myocardial infarction - YASS was used for Comparative genome analysis of non-coding DNA sequences.
• Recent speciation associated with range expansion and a shift to self-fertilization in North American Arabidopsis - YASS was used, where ?
• Architecture, Chromatin and Gene Organization of Toxoplasma gondii Subtelomeres - YASS was used to determine repetitive DNA regions.
• A family of unusual immunoglobulin superfamily genes in an invertebrate histocompatibility complex - YASS was used, where ?
• The relationship between transposable elements and ecological niches in the Greater Cape Floristic Region: A study on the genus Pteronia (Asteraceae) - YASS was used to analyse Contigs containing arrays of discovered satDNA families.
• Introgression between highly divergent sea squirt genomes: an adaptive breakthrough? - YASS was used, where ?
• The structural diversity of CACTA transposons in genomes of Chenopodium species - YASS doplot was used to compare CACTA-like elements (Fig 2).
• Bioinformatics Approaches for Analyzing Multigene Families Encoding Immune Receptors - ().
• Bilateral free flap breast reconstruction using venous cross-over bypass to contralateral internal mammary artery for salvaging thrombosed arterial anastomosis in unilateral repeated irradiation of the breast: A case report - ().
• Long-read sequencing reveals atypical mitochondrial genome structure in a New Zealand marine isopod - YASS was used for a self-self dotplot of the full-length mitochondrial genome.
• Comparative Whole Genome Analysis of an Anaplasma phagocytophilum Strain Isolated from Norwegian Sheep - YASS was used to compare sequences of the 16S rRNA gene and the groESL operon.
• Novel insertions in the mitochondrial maxicircle of Trypanosoma musculi, a mouse trypanosome - Dotplot graphs of the T. musculi maxicircle sequence plotted against itself and four other Trypanosomatidae species were generated by YASS.
• Comparative repeatome analysis reveals new evidence on genome evolution in wild diploid Arachis (Fabaceae) species - The selected genome regions were analyzed for tandem repeat organizations using the YASS genomic similarity tool.
• Maxicircle architecture and evolutionary insights into Trypanosoma cruzi complex - YASS doplot was used to self-self maxicircle.
• Reproductive isolation among lineages of Silene nutans (Caryophyllaceae): A potential involvement of plastid-nuclear incompatibilities - ().
• SVA retrotransposons and a low copy repeat in humans and great apes: a mobile connection - YASS was use to generate dotplots.
• A mechanism for red coloration in vertebrates - ().
• Origin of an antifreeze protein gene in response to Cenozoic climate change - Dot plot comparison of the mRNA sequences of Gig2–3 to S1 generated using YASS.
• Evolution of variable lymphocyte receptor B antibody loci in jawless vertebrates - The genomic dot plot was generated with the YASS genomic similarity search tool.
• Comparative Analysis of Transposable Elements in Genus Calliptamus Grasshoppers Revealed That Satellite DNA Contributes to Genome Size Variation - YASS was used to search for tandem repeats.
• TAQing2.0 for genome reorganization of asexual industrial yeasts by direct protein transfection - YASS was used to connect contigs.
• Group II intron and repeat-rich red algal mitochondrial genomes demonstrate the dynamic recent history of autocatalytic RNAs - Analysis of genome similarity using the YASS program.
• Identification and characterization of a new family of long satellite DNA, specific of true toads (Anura, Amphibia, Bufonidae) - YASS was used to perform Doplot analysis.
• Convergent copy number increase of genes associated with freshwater colonization in fishes - YASS was used to conduct Local pairwise alignment.
• From telomere to telomere: The transcriptional and epigenetic state of human repeat elements - YASS was used, at least from what i understand ;-).
• Reevaluation of the Toxoplasma gondii and Neospora caninum genomes reveals misassembly, karyotype differences, and chromosomal rearrangements - Fig 4, Inverted repeat sequence is graphically represented in a YASS plot.
• Genome Comparisons of the Fission Yeasts Reveal Ancient Collinear Loci Maintained by Natural Selection - YASS was used to create whole genome dot plots.
• Evaluation of four methods to identify the homozygotic sex chromosome in small populations - YASS was used to map scaffolds from an incompletely assembled reference genome.
• Deep Conservation of Hid-Like RHG Gene Family Homologs in Winged Insects Revealed by “Taxon Hopping” BLAST - Sequence similarity dot blot of the A. pisum RHG coding region DNA sequence XM_001950167.5 were generated with YASS.
• Different kinetoplast degradation patterns in American Trypanosoma vivax strains: Multiple independent origins or fast evolution? - Self comparison of IB (left panel) and Y486 (right panel) using YASS dot-plot representation (Fig. 1).
• Searching for a Needle in a Haystack: Cas9-Targeted Nanopore Sequencing and DNA Methylation Profiling of Full-Length Glutenin Genes in a Big Cereal Genome - the dot plot was constructed by YASS.
• Identification of strains of a bacterial species from long reads - Perspectives: the use of indel seeds ;-) .
• Sequence diversity, locus structure, and evolutionary history of the SpTransformer genes in the sea urchin genome - Dot plots were generated using YASS.
• Finding and Characterizing Repeats in Plant Genomes - ().
• Episodes of Rapid Recovery of the Functional Activity of the ras85D Gene in the Evolutionary History of Phylogenetically Distant Drosophila Species - YASS was used to reveal forward and inverted repeats.
• Formation of artificial chromosomes in Caenorhabditis elegans and analyses of their segregation in mitosis, DNA sequence composition and holocentromere organization - YASS was used to plot AC contigs to yeast genome and self-alignment of AC contigs.
• Genome Plasticity by Insertion Sequences Learned From a Case of Radiation-Resistant Bacterium Deinococcus geothermalis - YASS was used to compare the genome sequence of D. geothermalis DSM11300T to that of Deinococcus sp. S9 strain.
• Three genomes in the algal genus Volvox reveal the fate of a haploid sex-determining region after a transition to homothallism - YASS was use to plot rearranged genomic regions or SDR.
• Engineered sex ratio distortion by X-shredding in the global agricultural pest Ceratitis capitata - YASS was used to do "back mapping".
• Complete minicircle genome of Leptomonas pyrrhocoris reveals sources of its non-canonical mitochondrial RNA editing events - YASS was used to do some "repeat finding".
• Patterns and tempo of PCSK9 pseudogenizations suggest an ancient divergence in mammalian cholesterol homeostasis mechanisms - YASS was used to manually assemble contigs by sequence alignments with genomic sequences from another species.
• The Novel Halovirus Hardycor1, and the Presence of Active (Induced) Proviruses in Four Haloarchaea - Dot plot comparison used the YASS alignment tool.
• Increased photosystem II translation efficiency as an important photoprotective mechanism in an Arabidopsis thaliana ecotype (Tibet-0) adapted to high light environments - YASS was used to compare the sequence variation between Tibet-0 and the A. thaliana reference chloroplast genome.
• The Landscape of the Genomic Distribution and the Expression of the F-Box Genes Unveil Genome Plasticity in Hexaploid Wheat during Grain Development and in Response to Heat and Drought Stress - YASS was used to analyse a local duplication event.
• Identification of novel avian and mammalian deltaviruses provides new insights into deltavirus evolution - YASS was used to provide self dot-plot analyses of linear deltavirus contigs.
• Evolutionary dynamics of transposable elements and satellite DNAs in polyploid Spartina species - YASS dotplot was used to identify satellite sequences with “self-to-self” sequence comparisons.
• Catalytically inactive Cas9 impairs DNA replication fork progression to induce focal genomic instability - YASS dotplot was used to analyse nanopore sequencing data.
• Identification of tandem repeat families from long-read sequences of Humulus lupulus - YASS was used to group reads with TR into families.
• Linkage mapping and QTL analysis of pecan (Carya illinoinensis) full-siblings using genotyping-by-sequencing - YASS was used to visualize and extract the best alignment.
• The major satellite DNA families of the diploid Chenopodium album aggregate species: Arguments for and against the “library hypothesis” - YASS was used to analyse contigs.
• A New Pneumococcal Capsule Type, 10D, is the 100th Serotype and Has a Large cps Fragment from an Oral Streptococcus - YASS dotplot was used to examine locus for synteny and homology.
• VIRIDIC—A Novel Tool to Calculate the Intergenomic Similarities of Prokaryote-Infecting Viruses - YASS was used to compare viral genomes.
• Genome-wide analysis, expansion and expression of the NAC family under drought and heat stresses in bread wheat (T. aestivum L.) - YASS was used to get homologies between TacNAC genes.
• Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres - YASS was used to scan C. sojae and C. viswanathii for the presence of inverted repeats.
• Genotyping and De Novo Discovery of Allelic Variants at the Brassicaceae Self-Incompatibility Locus from Short-Read Sequencing Data - YASS was used to align consensus contigs against sequences of the SRK database.
• Replication of the Salmonella Genomic Island 1 (SGI1) triggered by helper IncC conjugative plasmids promotes incompatibility and plasmid loss - YASS was used to search for direct and inverted sequence repeats.
• Genomic Profiling by ALaP-Seq Reveals Transcriptional Regulation by PML Bodies through DNMT3A Exclusion - YASS dotplot was used to analyse YS300 sequence.
• Transposons and satellite DNA: on the origin of the major satellite DNA family in the Chenopodium genome - YASS dotplot was used to provide self-to-self comparisons of the three Oxford Nanopore ultralong reads from the C. acuminatum genome (Fig 2).
• A novel Borrelia species, intermediate between Lyme disease and relapsing fever groups, in neotropical passerine-associated ticks - YASS was used to perform Dot plot analyses.
• The first mitochondrial genomes of endosymbiotic rhabdocoels illustrate evolutionary relaxation of atp8 and genome plasticity in flatworms - YASS was used to scan for repeats.
• Complex mosaic structural variations in human fetal brains - YASS was use to determine breakpoints for each rearrangement between the assembled contigs against the reference genome.
• Comparative genomics of two new HF1-like haloviruses - YASS was use to produce dotplots of Figure 2.
• Alternative splicing reverses the cell-intrinsic and cell-extrinsic pro-oncogenic potentials of YAP1 - YASS was used to generate dot plots for Ccl2 promoter regions between human and mouse.
• Characterization and dynamics of repeatomes in closely related species of Hieracium (Asteraceae) and their synthetic and apomictic hybrids - YASS was used for the discovery of potential tandem repeats.
• Transcriptome-wide single nucleotide polymorphisms related to electric organ discharge differentiation among African weakly electric fish species - YASS was used to discard remaining paralogs.
• The involvement of U-type dicentric chromosomes in the formation of terminal deletions with or without adjacent inverted duplications - YASS was use to get the length of the inverted sequence homology.
• Genetic Engineering by DNA Recombineering - YASS is proposed to search for problematic repetition (syntenic dotplot).
• The Draft Genome of Kochia scoparia and the Mechanism of Glyphosate Resistance via Transposon-Mediated EPSPS Tandem Gene Duplication - YASS was used to align a BAC to the susceptible contig from the Kochia genome assembly containing the EPSPS gene.
• Greedily assemble tandem repeats for next generation sequences - YASS was used to realign tandem repeats of the human chromosome 14 from the tandem repeat database (TRDB) to the human reference.
• Complete genome and bimodal genomic structure of the amoebal symbiont Neochlamydia strain S13 revealed by ultra-long reads obtained from MinION - selected reads were aligned with YASS.
• A Schwann cell–enriched circular RNA circ-Ankib1 regulates Schwann cell proliferation following peripheral nerve injury - YASS was used to analyse the sequences of intron 1 and intron 5 of gene Ankib1 (RGSC 5.0/rn5).
• Rapid evolution of α-gliadin gene family revealed by analyzing Gli-2 locus regions of wild emmer wheat - dotplots of regions of the wild emmer and hexaploid wheat Chinese Spring were performed using YASS.
• A key metabolic gene for recurrent freshwater colonization and radiation in fishes - Local genomic similarity of the Fads2 regions between LG12 and LG19 was analyzed using YASS.
• Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability - DNA local alignment analysis of the NCBI hg19 reference sequence of chromosome 7 was performed using YASS.
• Polyunsaturated fatty acid production by Yarrowia lipolytica employing designed myxobacterial PUFA synthases - Polyadenylation signals were avoided as well as long sequence repeats with YASS.
• Reprogramming of Retrotransposon Activity during Speciation of the Genus Citrus - dot plot was performed using YASS.
• The first next-generation sequencing approach to the mitochondrial phylogeny of African monogenean parasites (Platyhelminthes: Gyrodactylidae and Dactylogyridae) - repeat regions were checked with Tandem Repeats Finder and YASS.
• Expansion and Functional Diversification of SKP1-Like Genes in Wheat (Triticum aestivum L.) - YASS was used to produce dot-plot of Figure 3.
• The conservation landscape of the human ribosomal RNA gene repeats - Other sequence elements in the IGS were identified using YASS and BLAST.
• npInv: accurate detection and genotyping of inversions using long read sub-alignment - YASS dotplot was used to detect NAHR inversion.
• De novo assembly of a young Drosophila Y chromosome using single-molecule sequencing and chromatin conformation capture - dot plots were produced using mummerplot, symap42, or YASS.
• Natural History of a Satellite DNA Family: From the Ancestral Genome Component to Species-Specific Sequences, Concerted and Non-Concerted Evolution - YASS was used to produce dot-plot of Figure 2.
• Expanding an expanded genome: long-read sequencing of Trypanosoma cruzi - YASS dotplot was used to compare contigs.
• Can Interspecies Hybrid Zygosaccharomyces rouxii Produce an Allohaploid Gamete? - YASS dotplot was used to examined the genome-wide synteny and identity between C. versatilis and Z. rouxii.
• Mapping of Hieracium (Asteraceae) chromosomes with genus‑specific satDNA elements derived from next‑generation sequencing data - YASS dotplot was used to seach for more fuzzy repeats for potential tandem organization.
• The comparison of four mitochondrial genomes reveals cytoplasmic male sterility candidate genes in cotton - YASS was used to analyse mitogenomes.
• Anisogamy evolved with a reduced sex-determining region in volvocine green algae - YASS dotplot was used to examine scaffolds between haplotypes to detect the rearranged genomic regions of MT.
• Clustering of circular consensus sequences:accurate error correction and assembly of single molecule real-time reads from multiplexed amplicon libraries - YASS was used to generate dot plots for alignments between the consensus sequences formed by LAA and their expected amplicon sequence.
• Identification of novel polymorphisms and two distinct haplotype structures in dog leukocyte antigen class I genes: DLA-88, DLA-12 and DLA-64 - YASS dotplot was used to align DLA-class 1 segments.
• Characterization of the ICCE Repeat in Mammals Reveals an Evolutionary Relationship with the DXZ4 Macrosatellite through Conserved CTCF Binding Motifs - YASS was used to generate pairwise alignments of the ICCE Repeat.
• Assembly of Schizosaccharomyces cryophilus chromosomes and their comparative genomic analyses revealed principles of genome evolution of the haploid fission yeasts - YASS and Mauve were used to identify chromosomal breakpoints.
• Reassessment of the evolution of wheat chromosomes 4A, 5A, and 7B - YASS was used to search for satellite DNA in breakpoint regions.
• The Sorghum bicolor reference genome: improved assembly, gene annotations, a transcriptome atlas, and signatures of genome organization - YASS was used to identify internal tandem direct repeats.
• Analysis of human ES cell differentiation establishes that the dominant isoforms of the lncRNAs RMST and FIRRE are circular - YASS was used to perform Dot matrix analyses.
• Draft chloroplast genome of Larix gmelinii var. japonica: insight into intraspecific divergence - YASS dotplot was used to validate the structure of L. gmelinii and L. decidua cp genomes.
• Whole-Genome Sequence of the Fruiting Myxobacterium Cystobacter fuscus DSM 52655 - YASS dotplot was used to inspect the final contig.
• Whole-genome assembly of Babesia ovata and comparative genomics between closely related pathogens - YASS dotplot was used to align the reordered contigs and the B. bigemina genome.
• Structure and diversity of the rhesus macaque immunoglobulin loci through multiple de novo genome assemblies - YASS dotplot was used to analyse diversity.
• Progress in identifying epigenetic mechanisms of xenobiotic-induced non-genotoxic carcinogenesis - YASS dotplot was used to align local genomic regions between orthologous mouse and human.
• A Pectin Methylesterase ZmPme3 Is Expressed in Gametophyte factor1-s (Ga1-s) Silks and Maps to that Locus in Maize (Zea mays L.) - YASS was used to analyse the structure of the W22 PME repeat region.
• Approaches for in silico finishing of microbial genome sequences - YASS was cited in Gap closing and Assembly evaluation.
• The plastid genome in Cladophorales green algae is encoded by hairpin chromosomes - YASS was used to generate dotplots for all contigs.
• Complete Genome Sequence of the Fruiting Myxobacterium Melittangium boletus DSM 14713 - YASS was used to inspect contigs.
• Evolution of sequence-specific anti-silencing systems in Arabidopsis - YASS dotplot was used to plot VANC genes.
• The unusual S locus of Leavenworthia is composed of two sets of paralogous loci - YASS was used to identify distant similarities with short sequences.
• Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-d-mannosamine in the orexin neurons derived from human iPS cells - dot-plots for the HCRT gene locus were generated with YASS.
• Divergence of annual and perennial species in the Brassicaceae and the contribution of cis-acting variation at FLC orthologues - YASS was used to align AmFLC genomic region and AmFLC cDNA.
• Concerted evolution rapidly eliminates sequence variation in rDNA coding regions but not in intergenic spacers in Nicotiana tabacum allotetraploid - YASS (dotplot) was used to provide “self-to-self” comparisons of IGS consensus sequences.
• Wild tobacco genomes reveal the evolution of nicotine biosynthesis - YASS was used to search for Transposable Elements.
• Higher-order organisation of extremely amplified, potentially functional and massively methylated 5S rDNA in European pikes (Esox sp.) - YASS was used to align reads to the 5S rDNA unit NGS consensus.
• DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome - YASS was used to look for Alu elements that can base pair with each other.
• TRA: tandem repeat assembler for next generation sequences - YASS was used to align tandem repeats from TRDB to the human genome.
• Ablation of RNA interference and retrotransposons accompany acquisition and evolution of transposases to heterochromatin protein CENPB - YASS was used to analyse codon usage bias.
• Establishment of DNA methylation patterns of the Fibrillin1 (FBN1) gene in porcine embryos and tissues - YASS was used to align FBN1 CpG islands among pig, human, mouse.
• Gene conversion events and variable degree of homogenization of rDNA loci in cultivars of Brassica napus - YASS was used to analyse subrepeats
• Short tandem repeats, segmental duplications, gene deletion, and genomic instability in a rapidly diversified immune gene family - YASS was used to compare five genes plus the intergenic sequences and flanking regions.
• A portrait of ribosomal DNA contacts with Hi-C reveals 5S and 45S rDNA anchoring points in the folded human genome - YASS was used to detect structural similarities among the contigs.
• Genetic basis for high population diversity in Protea-associated Knoxdaviesia - YASS dot-plot was used to compare idiomorphs (dissimilar alleles).
• Exaptation of Bornavirus-Like Nucleoprotein Elements in Afrotherians - YASS dot-plot was used to perform analysis of the genes of interest.
• IncA/C Conjugative Plasmids Mobilize a New Family of Multidrug Resistance Islands in Clinical Vibrio cholerae Non-O1/Non-O139 Isolates from Haiti - YASS was used to analyse MGIVchHai6, a mobilizable genomic island (MGI).
• Enrichment by hybridisation of long DNA fragments for Nanopore sequencing - YASS was used to align HCMV nanopore reads to the HCMV HHV-5 reference.
• Mitochondrial Genome Analysis of Wild Rice (Oryza minuta) and Its Comparison with Other Related Species - YASS dot-plot was used to analyse similarities.
• Evidence for the sexual origin of heterokaryosis in arbuscular mycorrhizal fungi - YASS was used to align scaffolds.
• The mitochondrial genome of the egg-laying flatworm Aglaiogyrodactylus forficulatus (Platyhelminthes: Monogenoidea) - YASS dot-plot was used to detect repeat regions.
• Discovery and profiling of small RNAs responsive to stress conditions in the plant pathogen Pectobacterium atrosepticum - YASS was used to align sRNA candidate signatures.
• Decoding the oak genome: public release of sequence data, assembly, annotation and publication strategies - YASS was used to detect overlapping fragments.
• Identification of genetic and environmental factors stimulating excision from Streptomyces scabiei chromosome of the toxicogenic region responsible for pathogenicity - YASS was used to find candidate attachment sites : searching for short repeated sequences.
• Draft genome of a commonly misdiagnosed multidrug resistant pathogen Candida auris - YASS was used to generate dot-plots.
• An epigenetic regulatory element of the Nodal gene in the mouse and human genomes - YASS was used to generate dot-plots.
• YOC, A new strategy for pairwise alignment of collinear genomes - YASS was used in "Phase 1: Similarity detection".
• GMcloser: closing gaps in assemblies accurately with a likelihood-based selection of contig or long-read alignments - YASS was used to generate pairwise alignment between the subcontigs of a gap.
• Phylogenetic analysis of HSP70 gene of Aspergillus fumigatus reveals conservation intra-species and divergence inter-species - YASS was used to generate dot-plots and alignments.
• Dominance hierarchy arising from the evolution of a complex small RNA regulatory network - Some precursor motifs within S-alleles were searched with YASS.
• The Rsm regulon of plant growth-promoting Pseudomonas fluorescens SS101: role of small RNAs in regulation of lipopeptide biosynthesis - sRNA searches were performed by Blast and YASS against the Rfam database (RNAspace package).
• Expression of a transferred nuclear gene in a mitochondrial genome - YASS was used to align TAIR sequences against A. thaliana mitochondrial genome.
• Head formation: OTX2 regulates Dkk1 and Lhx1 activity in the anterior mesendoderm - "Mouse and human genomic sequence were analysed with the University of California, Santa Cruz (UCSC) genomic browser and YASS".
• Genome of brown tide virus (AaV), the little giant of the Megaviridae, elucidates NCLDV genome expansion and host–virus coevolution - "Whole genome dot plot was constructed in YASS (Yet Another Similarity Searcher) server".
• Subcellular localization of minicircle DNA in the dinoflagellate Amphidinium massartii - YASS was used to align the non-coding region of the Dinoflagellate minicircle DNA.
• A region of euchromatin coincides with an extensive tandem repeat on the mouse (Mus musculus) inactive X chromosome - Dot plots of an extensive tandem repeat (on mouse chromosome X) were generated with YASS.
• A gene expression restriction network mediated by sense and antisense Alu sequences located on protein-coding messenger RNAs - the command-line version of YASS was used to search Alu elements in PCM1 against RefSeq.
• Dancing together and separate again: gymnosperms exhibit frequent changes of fundamental 5S and 35S rRNA gene (rDNA) organisation - YASS was used to identify rRNA coding sequences using dotplots.
• Bioinformatics Tools for the Multilocus Phylogenetic Analysis of Fungi - YASS is listed as a tool used for multilocus phylogenetics analysis in fungi.
• Arabidopsis thaliana Resistance to Fusarium Oxysporum 2 Implicates Tyrosine-Sulfated Peptide Signaling in Susceptibility and Resistance to Root Infection - Initial alignments of intergenic regions in Col-0 and Ty-0 sequences were generated with YASS.
• RNA at 92 °C: The non-coding transcriptome of the hyperthermophilic archaeon Pyrococcus abyssi - YASS was used in one filter for potential RNA targets.
• The tRNAarg Gene and engA Are Essential Genes on the 1.7-Mb pSymB Megaplasmid of Sinorhizobium meliloti and Were Translocated Together from the Chromosome in an Ancestral Strain - Dot plots were generated with YASS.
• Evolution of the Chloroplast Genome in Photosynthetic Euglenoids: A Comparison of Eutreptia viridis and Euglena gracilis (Euglenophyta) - YASS was used to produce the dot plot between the two chloroplast genomes.
• The macrosatellite DXZ4 mediates CTCF-dependent long-range intrachromosomal interactions on the human inactive X chromosome - Pairwise regions of Dxz4 were aligned using YASS.
• The mouse DXZ4 homolog retains Ctcf binding and proximity to Pls3 despite substantial organizational differences compared to the primate macrosatellite - Alignments and Dot plots were generated with YASS.
• Ortholog Alleles at Xa3/Xa26 Locus Confer Conserved Race-Specific Resistance against Xanthomonas oryzae in Rice - YASS was used to produce the Pair-wise sequence comparisons of Xa3/Xa26.
• RNAspace.org: An integrated environment for the prediction, annotation, and analysis of ncRNA - YASS is used to produce alignments of RNAspace.
• Uncovering the Prevalence and Diversity of Integrating Conjugative Elements in Actinobacteria - YASS was used to identify the direct repeats of the attL and attR attachment sites.
• Detection of small RNAs in Bordetella pertussis and identification of a novel repeated genetic element - YASS was used to indentify Bordetella pertussis sRNAs.
• The human gut virome: Inter-individual variation and dynamic response to diet - YASS was used to assess similarity between VLP contigs.
• Homoplastic microinversions and the avian tree of life - YASS was used together with Blast to detect microinversions.
• An alternative approach to multiple genome comparison - YASS is used (together with other tools) to compute initial pairwise alignments.
• Structural and content diversity of mitochondrial genome in beet: a comparative genomic analysis - YASS was used for various analyses (chimeric ORFs detection, duplication detection, ...).
• Comprehensive prediction of chromosome dimer resolution sites in bacterial genomes - YASS was used together with Blast to predict dif/XerCD systems.
• Cis-regulatory characterization of sequence conservation surrounding the Hox4 genes - YASS was used to determine CNEs alignments in zebrafish.
• A scenario of mitochondrial genome evolution in maize based on rearrangement events - YASS was used to compute markers.
• Sequence analysis of two alleles reveals that intra- and intergenic recombination played a role in the evolution of the radish fertility restorer (Rfo) - YASS was used to align the two alleles sequences.
• dif/Xer Recombination Systems in Proteobacteria - YASS was used to identify dif-related sequences in proteobacteria.
• Evolutionary dynamics of a locus of fertility restoration in plants - YASS was used to analyse the similarity between alleles and inside the studied allele.
• Mapping of 5q35 chromosomal rearrangements within a genomically unstable region - YASS was used to search for similarities, and YASS dotplot provided positional information.
• The genome sequence of the model ascomycete fungus Podospora anserina - YASS was used together with Erpin and Blast to detect non-coding RNAs.
• Diversity and structure of PIF/Harbinger-like elements in the genome of Medicago truncatula - YASS was used to align Transposable elements.
• Mammalian Small Nucleolar RNAs Are Mobile Genetic Elements - YASS was used to align genomic segments.
• Genomic architecture of human 17q21 linked to frontotemporal dementia uncovers a highly homologous family of low-copy repeats in the tau region - YASS was used to analyse contig sequences for LCR regions.
• sno-RNA database - YASS was used to produce human and yeast rDNAs alignments.
• A fast and flexible approach to oligonucleotide probe design for genomes and gene families - Transition constrained seeds were used to filter potential oligonucleotides.
• SinicView : multiple alignment comparisons - famous YASS matrix used. ;-)
• Seeds for effective oligonucleotide design - Iedera was used to design spaced seeds.
• Adaptive seeds tame genomic sequence comparison - LAST software and adaptative seeds.
• Spaced seeds for cross-species CDNA-to-genome sequence alignment - review spaced seed design and focus on cross-species sequence alignment.
• A Genomic Distance Based on MUM Indicates Discontinuity between Most Bacterial Species and Genera - maximal unique matches (MUM) based distance for full genomes.
• A survey of seeding for sequence alignment - a survey of the different approaches proposed to index genomic or amino-acid sequences.
• Run Probability of High-Order Seed Patterns and its Applications to Finding Good Transition Seeds - a new heuritic is proposed to quickly select good (either optimal) transition seeds.
• Good spaced seeds for homology search - this paper provides a list of single spaced seeds. Note that you can also conceive multiple spaced seeds/transition constrained seeds with our Hedera tool to fit more specific repeats if needed.
• Superiority of Spaced Seeds for Homology Search - 2 very interesting results about the number of non overlapping hits, and the asymptotic hit probability.
• Quick, Practical Selection of Effective Seeds for Homology Search - leakage model for effective seed design.
• Hardness of Optimal Spaced Seed Design - Given spaced seed sensitivity estimation (lossy filtering) or the guaranty of 100% sensitivity (lossless filter) is difficult, even for one single seed.
• Fast Computation of Good Multiple Spaced Seeds - how to speed up the seed design.
• Indel seeds for homology search - a new seed model and its waiting time formula.
• All hits all the time: parameter free calculation of seed sensitivity - or how to compute (with a single polynom) seed sensitivity for any similarity parameter.
• BDD-Based Analysis of Gapped q-Gram Filters - lossless filter and analysis of such seeds.
• Ribosomal RNA as molecular barcodes: a simple correlation analysis without sequence alignment - Composition Vector Analysis (method without alignments) to construct phylogeny trees.
• Métagénomique Bactérienne et Virale - sur le domaine plein d'avenir qu'est la métagénomique.
• A Minimum Cost Process in Searching for a Set of Similar DNA Sequences - KMP filtering method applied to DNA search.
• Wikipedia sequence alignment software - nice resource for tools.
• Wabim list of software - an impressive (and up to date) list of biological tools.
• MIGale Bioinformatics platform - by the INRA MIG team.